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Central GLP-1R activation in hypothalamic and mesolimbic pathways may lead to fatigue, lethargy, or brain fog 63 , though such effects might be often transient and dose-dependent

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AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells

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Hypertension, 80 (1), 115-123