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3.C), whereas tirzepatide again showed a more pronounced effect (MD: 5.76 mmHg

In brief, glucose is transported into the beta-cell via the glucose transporter 2 (Glut2) in rodents (GLUT1 and 3 in humans), converted to pyruvate, and shuttled into the mitochondria where it is used for ATP production (18)

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At year 2, high-density lipoprotein cholesterol significantly increased with liraglutide 2.4/3.0 mg versus orlistat (treatment difference 0.07 mmol l 1 , P =0.03), and both low-density lipoprotein cholesterol and triglycerides decreased from randomization with liraglutide 2.4/3.0 mg (treatment difference 0.12 mmol l 1 for triglycerides, P =0.053 versus orlistat)

The expected clinical escalation protocol moves through 2mg, 4mg, 8mg, and up to 12mg over the course of approximately 12 weeks