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The synergy between the two pathways is what makes the combination dosing more efficient per unit of compound

Moreover, participants with an adherence rate of less than 90% or those unwilling to continue the study were planned to be excluded, concerning the per-protocol method

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A box was constructed to fully enclose the small molecule and protein by adjusting the Grid Box parameters, followed by running AutoGrid 4, setting the docking parameters and algorithms, running AutoDock4, and exporting the results file in PDBQT format

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