alcohol use and glp 1 Medscape | Once weekly semaglutide injections reduced consumption in patients with alcohol disorder comorbid obesity. Results of the GLP-1 shifts alcohol market dynamics

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This observed result was achieved by reducing mitochondrial membrane potential, increasing ROS levels in mitochondria, upregulating pro-apoptotic genes (Bad, Bid, Caspase-9, and Caspase-3), and downregulating the anti-apoptotic Bcl2 gene (151)

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Semaglutide and tirzepatide are potent GLP-1 drugs that also trigger weight loss through appetite suppression and metabolic effects

Three Klebsiella species as potential pathobionts generating endogenous ethanol in a clinical cohort of patients with auto-brewery syndrome: a case control study