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These structural modifications result in significantly reduced binding affinity for IGF-binding proteins (IGFBPs), thereby extending the compounds effective half-life in cell culture systems compared to native IGF-1

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The ERK-CREB cascade has been proven to be involved in neurodevelopmental processes, neuroplasticity, stress responses, and neurocognitive functions [72]

It has a free sulfhydryl group (-SH) from the cysteine amino acid that can donate electrons to neutralize free radicals and reactive oxygen species

Preclinical models show activity at 24 weeks