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It has not completed human clinical trials

It mimics the effects of exercise at a cellular level and enhances metabolic flexibility , allowing the body to switch more efficiently between using carbs and fat as fuel

The math on the cycle cost favors the vendor-supplied bottle

Each bottle contains 20mg total

Some studies cited in a 2025 review noted that while proline can protect cells at low levels, when metabolized by the enzyme proline oxidase it produces reactive oxygen species (ROS)