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For example, the electrophysiological characteristics of dopaminergic neurons in the substantia nigra pars compacta change before the appearance of motor symptoms in parkinsonian mice (Qi et al., 2017), while excitatory stimulation of dopaminergic neurons may improve the survival of the neurons (Michel et al., 2013)

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Briefly, the radiolysis of cellular water generates highly oxidizing hydroxyl radicals which instantly abstract hydrogen atoms from the neighboring biomolecules, thus forming the alkyl radical (Fig