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Inhibition of this backup Okazaki fragment processing pathway leads to replication gaps underlying the synthetic lethality between PARPi and BRCA mutations (Cong et al, 2021)

Targeting one carbon metabolism with an antimetabolite disrupts pyrimidine homeostasis and induces nucleotide overflow

Atrazine oral exposure of peripubertal male rats downregulates steroidogenesis gene expression in leydig cells

NAD+ Therapy : Known for its role in cellular energy and longevity, NAD+ helps repair DNA, reduce inflammation, and support mitochondrial function

However, a landmark July 2025 study published in the Proceedings of the National Academy of Sciences (PNAS) by Shankar, Davis, Bonilla, et al., revealed a fascinating and complex paradox regarding redox homeostasis in these conditions

this improved performance was due to a reduction in oxidative stress and improved physiological performance