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The extravasation and trafficking of leukocytes in and out of the brain are also influenced by factors that can be released from pericytes and endothelial cells [31]

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Moreover, most clinical cancer therapies, including conventional chemotherapies 8 , radiotherapy 9 , or recent immune therapies 10,11 , have also been reported to undermine female fertility in various ways, which further distracts researchers attention on NRTP-induced ovarian damage