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Nrf2 activation regulates antioxidant responses to modify cellular redox states from predominantly pro-oxidant to antioxidant, and, in an antioxidant environment, macrophage phenotypes shift from M1 pro-inflammatory to M2 anti-inflammatory, reducing the probability of cytokine storms, ARDS, and lethality (Tan et al., 2016

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Nevertheless, preliminary studies that find the right non-toxic dosage is important, whether in vitro or in vivo as screening for study feasibility, but still, further human study is required to determine the dose safety and efficacy (Stohs and Hartman, 2015)

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"The hemodynamic effects of intravenous paracetamol (acetaminophen) vs normal saline in cardiac surgery patients: A single center placebo controlled randomized study"

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