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Network meta-analyses suggest that higher-dose semaglutide (1 mg and 2 mg weekly) and tirzepatide (a dual GIP/GLP-1 receptor agonist) demonstrate superior A1c reductions compared to other agents in the class, with mean reductions of 1.52.0% or greater from baseline

At a systems level, this work highlights the power of large health-system datasets, like the MHS, to evaluate rare outcomes and support evidence-informed decision-making

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BMC Medicine [Internet]

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