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Wu G 1 , Zhang L, Li T, Zuniga A, Lopaschuk GD, Li L, Jacobs RL, Vance DE

Human data semaglutide/tirzepatide: extensive, approved for type 2 diabetes and obesity

Studies have shown that hyperglycemia activated the production of inflammatory cytokines such as TNF, IL6, and IL1B, which contribute to kidney damage ( in vitro experiments demonstrated the anti-inflammatory activity of HU against HG-induced cell damage

GLP-1 slows the stomach and dampens appetite

As for clinical correlates, Vit B12 deficiency and HHcy do predict more rapid motor progression and cognitive dysfunction among PwPD and thus modulate PD clinical phenotypic variability

Many patients simplify their routine after starting prescription treatment