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True hypoglycemiadefined as blood glucose below 70 mg/dLtriggers a strong physiological drive to consume carbohydrates

doi: 10.3389/fnut.2025.1587246 Received 07 March 2025 Revised 16 November 2025 Accepted 28 November 2025 Published 17 December 2025 Volume 12 - 2025 Edited by Ingrid Lofgren, University of Rhode Island, United States Reviewed by Sergio A

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Patients were indexed on first observed therapy and followed until discontinuation, switch, or 12 months post index for persistent patients

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We also verified that internal Cys residues are unable to activate SetCys residue, which is therefore useful for the production of Cys-rich peptides such as conotoxin OIVA (Supplementary Methods, Supplementary Fig