Indeed, in clinical practice, metformin demonstrated a variety of beneficial effects on menstrual disorder, anovulation, androgen excess, insulin resistance, and cardiovascular risk, whereas its weight loss effect is often inconsistent and transient [21, 22]
That "competitive" weight loss appears to be driven by "rapid" dose increases, which caused a high frequency of gastrointestinal side effects, according to the Jefferies analysts
Ample evidence indicates that optimising metabolic health and using renin-angiotensin system inhibitors and sodium-glucose cotransporter-2 (SGLT-2) inhibitors can delay the progression of DKD
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1) These weight-loss drugs are not a short-term fix Different patients will have different considerations before deciding to take one of these new treatments
