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These ideas are in line with metalloproteomics experiments in Saccharomyces cerevisiae , which reveal that 20 cell-abundant Zn II metalloenzymes, if fully metalated, account for 90% of the zinc quota in the cell, one of which is methionine aminopeptidase
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Although there are more and more animal experiments on UPS modulating renal diseases, further exploration of its specific mechanism is needed
3.3.1 Ferroptosis inducers Small molecules targeting iron metabolism: Erastin was first identified in 2003 as a genetically selective antitumor agent that induces ferroptosis primarily through interaction with VDACs ( Small molecules targeting lipid metabolism: The antitumor agent sorafenib, in the presence of ACSL4, activates ferroptosis by directly affecting lipid ROS generation pathways ( Small molecules targeting the GSH/GPX4 axis: RSL3 and RSL5, although functionally distinct, were among the earliest identified GPX4-targeted ferroptosis inducers
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