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Indeed, early preclinical studies demonstrated attenuation of renal TGF- expression in association with reduced expression of collagens within the kidney after GLP-1 receptor agonist therapy (62)

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In 2004, researchers conducted a meta-analysis of 61 randomized controlled trials evaluating GLP-1 RAs, sodium-glucose co-transporter-2 inhibitors (SGLT2i), dipeptidyl peptidase 4 inhibitors (DPP-4i) and didnt find an increased risk of diabetic retinopathy events with GLP-1 RAs or any of the other classes of antihyperglycemic medications