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J Exp Clin Cancer Res 40(1):114 Kataoka T, Budd RC, Holler N, Thome M, Martinon F, Irmler M et al (2000) The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways

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That complex has a half-life of many hours, but the IGF-1 it carries is not free to bind IGF1R while complexed

It's not an instant solution, and continued use is often needed