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For example, older mice given nightly melatonin had levels of oxidative damage markers in brain and liver comparable to much younger mice, and they maintained better learning/memory performance than unsupplemented old mice (Jia et al., 2024

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Oncogene 24 , 47364740 (2005)

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doi: 10.1007/s11102-023-01340-5 218 MajdNWaguespackSGJankuFFuSPenas-PradoMXuMet al

Although these studies suggest RyR1 is affected by statins, ambiguity has remained on whether this is due to direct binding, by affecting an RyR1 binding partner (present in tissue and in SR vesicle preps), or by affecting signaling pathways that impinge on RyR1