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This effect was primarily mediated through weight loss, with different degrees of contributions from weight-loss independent effects across the different SURPASS trials

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this effect is explained by the delay of gastric emptying observed under tirzepatide administration (61)

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Kenniston JA, Taylor BM, Conley GP, Cosic J, Kopacz KJ, Lindberg AP, et al

We break this down further in our Tirzepatide for prediabetes guide