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Retrieved January 15, 2026, from Tempia Valenta S, Nicastri A, Perazza F, Marcolini F, Beghelli V, Atti AR, Petroni ML

3), with GSSG depleting over time without additional formation of ROS

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The SURMOUNT-4 trial assessed the weight maintenance with tirzepatide and had also two periods: a 36-week open-label lead-in period during which all participants took tirzepatide, followed by a 52-week double-blind treatment period during which participants were randomised to either continue on tirzepatide or switch to placebo

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injection), active ingredient (semaglutide vs