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Small Molecular Metabolite Targets for Treatment of Rheumatoid Arthritis Previous research has shown that small molecular metabolites, like PGs, LTs, LXs, PAF, ROS, and NO, support to induce, maintain, or relieve inflammation in RA ( Table 2 )

These include situations where metformin is ineffective, contraindicated, or when patients fail to reach their target glycemic control despite treatment with metformin and other medications

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Carbon 173 , 6979 (2021) Lu, X.F., Fang, Y., Luan, D., Lou, X.W.D.: Metalorganic frameworks derived functional materials for electrochemical energy storage and conversion: a mini review