In contrast, large-scale GLP-1R agonist outcome trials consistently show reduced risk of major adverse cardiovascular events, independently of comorbidities or weight loss achieved 62 suggesting that targeting downstream effector pathways of neural mechanisms of cardioprotection using GLP-1R agonists is a promising therapeutic strategy
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"Vitamin B12 deficiency can be sneaky, harmful"
The HPA axis normally triggers cortisol release during stress, but chronic activation leads to elevated baseline cortisol, which is linked to weight gain, inflammation, and metabolic dysfunction
33 An in vivo study showed that DMF restored apoptosis sensitivity and inhibited tumour growth and metastasis in cutaneous T-cell lymphoma by targeting NF-B
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