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Viability assay was also performed with combination of RSL3 and Fer1 (5 M) or ZVAD (50 M)

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Once you add bacteriostatic water, you've activated the compound

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Conventional epigenetic drugs, such as HDAC inhibitors or DNMTi, broadly alter chromatin states and often exhibit substantial off-target effects, limiting their suitability for treating depression or addiction in a targeted manner 196

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