It's a normal physiologic response to the medication's metabolic effects
Published Phase 2 trial data do not report week-4 weight loss as a primary outcome, as participants are in a dose-escalation titration phase during the first month
I also observed a worsening of pre-existing POTS symptoms a condition that, in hypermobile Ehlers-Danlos Syndrome, is not incidental but mechanistically downstream: a recognized consequence of defective extracellular matrix that can produce peripheral venous laxity, impaired lower-extremity vasoconstriction, chronic hypovolemia, and the compensatory hyperadrenergic state that characterizes the neuropathic POTS phenotype
323,324 In cardiovascular diseases such as hypertension and HF, vascular dysfunction contributes not only to abnormal blood pressure regulation but also to increased cardiac afterload, impaired tissue perfusion, and progressive end-organ damage
Liquid protein supplements, small frequent meals, and close monitoring of nutritional intake help ensure proper healing
However, second-round headaches are typically milder and shorter-lived than the initial episode because your nervous system has already learned to process GLP-1 signaling
