tirzepatide vs semaglutide weight loss side effects comparison difference in and Comparative safety of and tirzepatide: Implications for clinical decision-making obesity Tirzepatide vs Semaglutide: What's the

Mollan, MBChB, FRCOphth, PhD Honorary professor, University of Birmingham, EnglandConsultant neuro-ophthalmologist, University Hospitals Birmingham, England Disclosures: Mollan reports receiving grants or research income paid to her institution from National Institute of Health Research, UK Space Agency and Idiopathic Intracranial Hypertension UK

GLP-1 receptor activation slows gastric emptying, reduces appetite, and promotes satiety

Regular monitoring and dose regulation are therefore essential

Slower dose escalation reduces side effect intensity

Unlike intravenous administration, subcutaneous injections deliver medication into fatty tissue where any small air bubble is absorbed harmlessly by surrounding tissue

Oral options for GLP-1s are limited and initial data for DHT-GLP-1s promising, leading to the development of a series of studies that seek to find the best approach for a more convenient delivery method of this class of medicine