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These findings emphasize the importance of personalized treatment approaches that integrate metabolic, genetic, and environmental factors to optimize therapeutic outcomes

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While PCSK2 is the predominant prohormone convertase in -cells in non-pathological conditions, -cell PCSK1 immunoreactivity increases in rodent models of metabolic stress

Capehorn M, Ghani Y, Hindsberger C (2020) Once-Weekly Semaglutide Reduces HbA1c and Body Weight in Patients with Type 2 Diabetes Regardless of Background Common OAD: a Subgroup Analysis from SUSTAIN 24 and 10