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Mast cells (MCs) are stimulated and degranulate, releasing histamine, IL-6, IL-8, prostaglandin D2 and tumor necrosis factor-alpha (TNF)- together with IL-23 and IL-31 and other cytokines (48, 49)

5B, C), although it must be underlined that bispecific nanobodies and Durvalumab were used at the same concentrations (10 g/mL), namely the molar concentration of the bivalent nanobodies was six times higher

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Co-administration with methotrexate has been shown to prolong the drugs half-life and elevate steady-state trough concentrations [184], likely by reducing the formation of anti-drug antibodies (ADAs) that promote faster clearance

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