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It is triggered by activation of inflammatory caspases, such as caspase-1, via inflammasomes (e.g., NLRP3), leading to the release of pro-inflammatory cytokines IL-1 and IL-18 and resulting in membrane rupture

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[DOI] [PMC free article] [PubMed] [Google Scholar] 282.Weiss T, Carr RD, Pal S, et al

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Not only do these factors contribute to a visibly aged appearance, but they also enhance the risk of developing other skin conditions