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[12] GH release stimulates protein synthesis and nitrogen retention, which is the rationale for investigating GH secretagogues in catabolic states such as post-surgical recovery, critical illness, prolonged bedrest, and age-related muscle wasting (sarcopenia)

This is the most time-sensitive part of any trial search, because recruitment status changes month to month

Trials of once-weekly semaglutide injections documented average weight reductions of 5-10% of starting body weight by the 12-week mark

May 2015;3(3):491-5

The SURMOUNT-4 trial demonstrated that participants who achieved significant weight loss on tirzepatide and then continued treatment maintained their weight loss, while those switched to placebo regained substantial weight

It would have been more of a surprise if regulators hadn't approved the drug