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While the effect of exercise on TIRAP is not fully known, it is known that TIRAP is a critical component of monocyte response to gram-negative bacteria and thus increased expression post-exercise with supplementation may translate into an improved innate immune response to bacterial challenge (Schenk et al

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Furthermore, the study provides additional clinical evidence that pretreatment with naltrexone may attenuate the antidepressant effects of ketamine measured one day after a single dose

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