2.6 Integration of stereotactic radiotherapy with surgery and systemic therapy 2.6.1 SRT combined with surgery RCTs have established that adjuvant SRT following surgical resection of brain metastases improves local control compared to observation alone, and preserves NCF while maintaining local control when compared to WBRT (114))
Close agreement observed between trials and estimates from the database analyses for all endpoints except one supported the fitness of the design and data for assessing cardiovascular effectiveness and safety
The article says neither agent is universally better, because efficacy depends on individual physiology, metabolic markers, and how a given body responds to GLP-1 signaling
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