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effects diminish within 2-4 weeks of continuous use Ipamorelin: Maximum Selectivity Ipamorelin was designed specifically for selective GH release: GHS-R1a Selectivity: Activates only GH-releasing pathways at the receptor No Cortisol Effect: Does not stimulate ACTH or cortisol release No Prolactin Effect: Does not affect prolactin levels Minimal Appetite Effect: Unlike other GHRPs, does not significantly increase hunger No Cardiac Activity: Lacks Hexarelin's cardiac receptor effects No Desensitization: Effects maintain with continued use Key Trade-off: Hexarelin offers maximum acute GH release but with hormonal side effects and rapid desensitization

In contrast, Apoe / mice had an approximately doubled atherosclerotic burden and elevated plasma levels of TMA and TMAO (Koeth et al., 2013)

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