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In PD models, oral administration of Curli-producing bacteria enhanced -syn aggregation and motor deficits in mice, whereas germ-free or antibiotic-treated mice had less -syn pathology [91, 92]

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Preclinical studies in rodents have demonstrated reductions in fat mass, improved insulin sensitivity, and increased metabolic rate without significant changes to food intake (Neelakantan et al., 2019)

This approach isn't used in clinical trials but is practised by some prescribers, particularly with compounded retatrutide

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Intercellular adhesion molecule-1 deficiency is protective against nephropathy in type 2 diabetic db/db mice