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Productivity Adjustment Section 1833(t)(3)(F)(i) of the Act requires that, for 2012 and subsequent years, the OPD fee schedule increase factor under subparagraph (C)(iv) be reduced by the productivity adjustment described in section 1886(b)(3)(B)(xi)(II) of the Act

(2015) Five Chinese patients with 5-oxoprolinuria due to glutathione synthetase and 5-oxoprolinase deficiencies, Brain Dev

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Additional symptoms include impaired wound and fracture healing, easy bruising, and loose or decaying teeth

Assay: Glutathione in mouse organ tissue