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Long-Term Maintenance Dosage After the titration phase, most patients stay on a consistent dose that maintains their results

IGF-1 DES has 20-30 minute half-life, minimal IGFBP binding, highest receptor affinity and potency, localized effects at injection site, and requires frequent dosing for sustained effects

The REDEFINE 1 Phase 3 trial extended this observation, showing 11.8% weight loss with cagrilintide 2.4 mg alone over 68 weeks

A growing body of evidence demonstrates that the tumor microenvironment, including cancer-associated fibroblasts (CAFs), can modulate drug sensitivity in tumor cells