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This causes ghrelin to rise and leptin to fall

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People with diabetes, particularly severe diabetes, tend to lose less weight with GLP-1s than people without diabetes, so microdosing is less likely to be as effective, though their dose should only be increased as they tolerate it. George said that in her professional opinion, microdosing is a potential option for patients with smaller amounts of weight to lose or as a bridge to start, or wean off, regular GLP-1 medications

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It triggers the pituitary to release GH in a pulsatile, physiological pattern

Saab SA and Nave KA (2017)