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Weight regain after weight loss is a multifactorial process driven by adaptive physiological responses - such as increased ghrelin, reduced leptin, lower peptide YY levels, and decreased energy expenditure - that promote appetite and energy conservation

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However, it is important to remember that there are no one-size-fits-all weight loss solutions

Based on current clinical evidence, tirzepatide (Zepbound) produces the highest average weight loss, followed by semaglutide (Wegovy), and then liraglutide (Saxenda)

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