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The triggering of macrophage inflammatory pathways is also a critical event in lesion development

Specifically, we found that acute incubation with the active form of vitamin D significantly upregulated the gene expression of endothelial (eNOS) and neuronal (nNOS) isoforms while concurrently downregulating inducible NOS (iNOS) expression

Potential pathways clinicians consider in similar contexts include: Blood pressure changes, including nocturnal hypotension NAION has been associated in some literature with low nighttime blood pressure