Gastrointestinal bleeding, ulcer disease, and hemorrhagic stroke remain clinically significant risks, particularly in older adults
These compounds reduce central neuroinflammation by lowering interleukin (IL)-1, IL-6, and tumor necrosis factor-alpha (TNF-), and limiting oxidative stress ( On the other side, current trends in precision psychiatry aim to classify subpopulations of patients with inflammatory depression, characterized by elevated markers of inflammation, increased glucose and lipid levels, neurovegetative symptoms, anxiety or irritability, and suicidal ideation (Wessa et al., 2026)
Small studies suggest semaglutide is not detectable in milk and tirzepatide is usually undetectable or very low when used in certain doses, but the issue remains understudied
But when it is taught through the lens of pathophysiology, through the biology of what is going wrong and the logic of what each medication is trying to fix, it becomes manageable
This phenomenon, known as the incretin effect, is greatly reduced in diabetics, a difference that led to the development of analogues of incretin GLP-1 and GIP
The Precision Peptide Genetic Test ($99 add-on) reveals whether semaglutide, tirzepatide, or dual-compound therapy is best for your genetic profile