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An update on the genetics, clinical presentation, and pathomechanisms of human riboflavin transporter deficiency

Both naturally decline with age, so people often add them to their routine

Jackson MJPS, Bolaos J, Bruckdorfer R, Carlssen H, Elliot RM, Flier J, Griffiths HR, Heales S, Holst B, Lorusso M, Lund E, Moskaug JO, Moser U, Di Paola M, Polidori MC, Signorile A, Stahl W, Via-Ribes J, Astley SB: Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function

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While its expression pattern varies across tumor types, CHAC1 is frequently upregulated in aggressive malignancies, such as breast and ovarian cancer, where it correlates with advanced tumor differentiation and potentially serves as a prognostic marker