2021;177 doi: 10.1016/j.addr.2021.05.017
Rapid dehydration was performed using graded ethanol (95% and 100%, 30 s each), followed by xylene clearance (twice, 5 min each)
Statistical analysis All experiments were replicated thrice independently with similar results
Loss of redox flexibility compromises protein thiol regulation, redox-sensitive signaling pathways, and endothelial homeostasis, positioning glutathione insufficiency as a primary upstream disturbance rather than a downstream consequence of disease (1-3)
The tripeptide glutathione, -L-glutamyl-L-cysteinyl-glycine, has come to the forefront as a nutritional bioactive with potential use in the management of NAFLD, as it plays a critical role in cellular antioxidant and detoxification systems
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