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It has been studied in preclinical models, cell cultures, and animal research for effects across a broader range of tissue types than most peptides of comparable size, including angiogenesis, nitric oxide signaling, and tendon, ligament, and muscle healing models

TB-500 supports cell migration, angiogenesis, and actin dynamics in wound and soft-tissue repair

called 'active vitamin B 12 '), and homocysteine (5)

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b , Model from AlphaFold prediction of TMEFF1 ectodomain (gold) with Nectin-1 ectodomain (orange)