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Lancet Diabetes Endocrinol 7(7):528539

Semaglutide for weight loss is typically prescribed to adults with: A body mass index (BMI) of 30 or higher (classified as obesity), or A BMI of 27 or higher (overweight) with at least one weight-related condition, such as high blood pressure, Type 2 diabetes, or sleep apnea

2011;107:123-6 Yoon SH

Endoplasmic reticulum stress induction and ERK1/2 activation contribute to nefazodone-induced toxicity in hepatic cells

The shared theme is satiety and slowed gastric emptying : both dampen appetite and delay stomach emptying, which plausibly contributes to reduced food intake

Among the most notable is the STEP 1 trial, a randomized, double-blind, placebo-controlled study