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You either have a body mass index (BMI) of 30 or above, or you have a BMI of 27 or above and a weight-related health condition (e.g

Low vitamin B12 levels are associated with having increased levels of homocysteine, contributing to higher levels of depression [2,3]

Cell Mol Life Sci 67(20):35493555 Kim Chung le T, Hosaka T, Yoshida M, Harada N, Sakaue H, Sakai T, Nakaya Y (2009) Exendin-4, a GLP-1 receptor agonist, directly induces adiponectin expression through protein kinase A pathway and prevents inflammatory adipokine expression

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Retrieved from Mayo Clinic

GLP-1s reduce appetite in the brain, so humans feel less hungry and are less bothered by persistent hunger