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(2020) 7:163 doi:10.3389/fmolb.2020.00163

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The HBMECs were cultivated at a density of 5 10 4 cells/well on the upper insert for 3 d, and the media were replaced with those containing OG488-LPs and Lf-OG488-LPs

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Intravesical treatments with heparin, hyaluronic acid, chondroitin sulfate, bacillus Calmette-Guerin, dimethylsulfoxide, and resiniferatoxin have been effective in treating IC/BPS, but the effects were not durable (Hanno et al., 2015)

The decrease of EPS production in late fermentation may be caused by the degradation of glycohydrolases presented in the culture for EPS synthesis