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doi: 10.3803/EnM.2021.1293, 16
How This Works Dihexa is a modified dipeptide-like molecule built from the tyrosine-isoleucine core of angiotensin IV , with both termini capped by hexanoic-acid-derived groups that raise lipophilicity and blunt enzymatic degradation the changes that gave it oral activity and blood-brain-barrier penetration [1]
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