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[DOI] [PMC free article] [PubMed] [Google Scholar] [Retracted] Starkey Lewis P
Anti-apoptotic effects of EPO (targeting primarily CFU-e and proerythroblasts) are mediated via pro-survival PI3K/Akt signaling activation [104], JAK2/STAT5-dependent upregulation of anti-apoptotic Bcl-XL [105, 106], JAK2/STAT5-dependent downregulation of pro-apoptotic Fas, FasL and BH3-only protein Bim [103], activation of the CK1-dependent caspase-10-P13tBid axis [107], and ERK-dependent degradation of Bim [108], summarized in Fig
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Given that TBI remains an area of significant unmet clinical need, these preclinical findings have positioned BPC-157 as a candidate worth further investigation in neurotrauma research
PLoS ONE 10(6):e0128423 Heumann D et al (1994) Gram-positive cell walls stimulate synthesis of tumor necrosis factor alpha and interleukin-6 by human monocytes
