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Overall Evidence for the Use of B12 for Painful Peripheral Polyneuropathy Taking into account the above evidence, there is level III evidence overall to support the use of B12 either as monotherapy or as a combination therapy for treating neuropathic pain caused by peripheral polyneuropathy

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Using it currently requires sourcing research-grade material, which involves additional quality verification, dosing calculations, and self-administration expertise

Think about it: if you're aiming to observe a specific cellular response or physiological change, an underdosed sample might show no effect at all, leading you to believe the compound is ineffective

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