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Managing constipation Why it happens: GLP-1 medications slow digestion, sometimes leading to constipation, especially if food and water intake decrease

Consistency also helps reduce side effects

Orforglipron may have higher rates of these side effects than oral semaglutide, and more people may discontinue orforglipron as a result

Notably, GLP-1-producing neurons within the nucleus tractus solitarius (NTS) project axons to the VTA and other limbic structures, further embedding GLP-1 signaling within neural networks that regulate reward and motivation (Llewellyn-Smith et al., 2011

Tirzepatide adds GIP (~20.9%)

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