Less common but more serious adverse events include pancreatitis, gallbladder disease (cholecystitis, cholelithiasis), severe gastroparesis or ileus, kidney injury, vision changes (particularly in patients with diabetic retinopathy), and serious allergic reactions
This is why it is labelled a conditionally essential nutrient
However, comprehensive clinical trials are needed to validate its efficacy
Previous microneedle patches for the same drug achieved only around 30% bioavailability
Finally, individuals with a history of heart failure, ischaemic heart disease, unstable angina, myocardial infarction, aortic aneurysm or dissection, stroke (ischaemic or haemorrhagic stroke), cerebral infarction, transient ischaemic attack, carotid intervention or surgery, coronary stenting, percutaneous coronary intervention (PCI) or coronary artery bypass before inclusion to the cohort or prior to the index event were also excluded
A phase I and pharmacokinetic study of selenomethionine in combination with a fixed dose of irinotecan in solid tumors